The goal of this project is to develop inhibitors targeting SARS-CoV-2 protease and test their efficacy in human lung organoids. Protocol A5404 SARS-CoV-2 Immune Responses after COVID-19 Therapy and Subsequent Vaccine California Institute for Regenerative Medicine CIRM 031721 Role: Co-Investigator Description: Protocol A5404 SARS-CoV-2 Immune Responses after COVID-19 Therapy and Subsequent Vaccine Role of anterior olfactory nucleus for multi-sensory integration in the olfactory system NIH R01DC019124 Jul 1, 2021 - Role: Co-Principal Investigator HIV Persistence and Renewal in the Gastrointestinal, Genitourinary and Adipose Tissues NIH R01DK131532 Sep 17, 2021 - Role: Principal Investigatorīrain Myeloid Cells are Sources of HIV-associated Damage and Viral Dispersal NIH R01DA055491 Jul 15, 2021 - Role: Co-Investigator This study will analyze and compare these processes, so that HIV cure research can focus on the critical obstacles to eradication of the virus from these under-studied organ systems. HIV Persistence and Renewal in the Gastrointestinal, Genitourinary and Adipose Tissues NIH/NIDDK 1R01DK131532 Sep 17, 2021 - Description: Duplication of HIV DNA by cell division, transmission of HIV RNA between cells within tissues, and trafficking of virus between these tissues may all contribute to HIV persistence. He has been elected as a fellow to the American Society of Clinical Investigation, American College of Physicians, and Infectious Diseases Society of America. In 2020, he was appointed the Florence Seeley Riford Chair in AIDS Research at UC San Diego. In 2017, he was promoted to Head of the Division of Infectious Diseases and Global Public Health at UC San Diego. He joined the UC San Diego faculty in 2003, and was promoted to full professor in 2012. He completed his internship, residency and chief residency in Internal Medicine at UC San Diego and stayed to complete his fellowship in Infectious Diseases. Smith graduated from East Tennessee State University School of Medicine in 1996. This study is designed to find effective therapies for persons with early COVID-19. In particular, he is the international protocol chair for the ACTIV-2 treatment study, which is a part of the US government’s Operation Warp Speed. Smith has been actively engaged in the international effort to find safe and effective treatments. Since the outbreak of SARS-CoV-2 in 2019, Dr. Smith was named HIV Researcher of the Year by the HIV Medical Association, and he became the co-director and principal investigator of the San Diego Center for AIDS Research (CFAR) in 2016. Smith's primary research involves both figuring out how to stop the transmission of HIV and curing HIV, and he has published over 200 scientific publications in these areas. In his translational research, he uses basic science techniques to answer clinically relevant questions. Davey Smith, MD, MAS, is an infectious disease specialist and translational research virologist.
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